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  • Bringing an extra dimension to Advance Pathology

At Phase Labs, we are designing automated diagnostic tools for faster, economical & efficient diagnosis of disease.

About PhaseLabs

Phase Laboratories was founded in 2016 and is incubated at IIT Delhi. Our team comprises of a bunch of scientists and research enthusiasts trained in diverse backgrounds, ensuring a multitude of requisite knowledge and varied perspectives on the table. We envision to combine quantitative phase imaging with automation to design novel diagnostic tools for providing improved and affordable health care technologies. Our aim is to characterize the morphology of biological samples with the help of phase information using Digital Holographic Microscope, and to use this extra dimension of information to develop smarter and efficient tools for diagnosing diseases.

Digital Holographic Microscope

The digital holographic microscope involves recording of a hologram or interference pattern between the object beam that passes through a specimen and a reference beam on a CMOS camera. Our DHM has the capability to capture and digitally record both the bright field images and holograms of the specimen with balanced 40x infinity corrected objectives. The holograms are then reconstructed to obtain the 3-dimensional phase profile of the specimen. Phase is an extra dimension of information that translates to the morphological structure of the specimen.

The novelty of our DHM lies in reconstruction of the phase map from a single-shot hologram with full resolution. The method also allows us to reconstruct a local hologram corresponding to the region-of-interest with full resolution that is not possible with the traditional Fourier transform approach.

Graphical User Interface

Graphical User Interface: We have developed a user friendly software that can generate 3-dimensional phase maps for both Red blood cells and Cervical Cells.

Our Technology

Automated Tool For Diagnosing Cervical Cancer

Cervical cancer is the second most common cancer among women worldwide. India has a population of 453.02 million women aged 15 years and older who are at risk of developing cervical cancer. Current estimates indicate that one women dies of cervical cancer every eight minutes in India. It takes one-two decades for cervical cancer to fully develop but lack of regular and effective screening, low doctor to patient ratio, and inadequate infrastructure account for high mortality rate.

Today, Pap smear test is the popular screening method to detect the abnormal cervical cells. The pathologists scan the microscope slide from the Pap test to study the morphological changes in the cell profile to label the patient sample as either normal or abnormal. On a routine day, a doctor spends more than fifteen minutes to examine a single slide. Further, in the pre-cancerous stages, approximately 1-2% of cells are affected. So, a doctor has to look for a needle in a haystack to correctly label the patient sample.

Our goal is to alleviate the burden on doctors by developing a standardized automated tool for classification of cervical cells into normal and abnormal with the help of quantitative phase imaging. The capability of the tool lies in effectively marking the abnormal cells within a slide for doctor to further investigate, thereby making the diagnostic process time efficient.

Red Blood Cells Profiling

Being an efficient and staining independent process, phase imaging can be used for understanding the profile of red blood cells (RBCs). It is a promising technique for individual profiling based on gender difference and Haemoglobin (Hb) content. The 3-dimensional phase map of RBCs provides a better insight about their morphological structure. A typical RBC has a lifespan between 100-120 days. During this period, it encounters different environments and undergoes multiple changes both structurally and biochemically. The phase profile of RBCs can be extensively studied to correlate the biochemical changes with the structural modification to better understand the underlying principles.

Using the powerful tool of phase imaging, we are trying to design a protocol which can be applied for differentiating individuals based on different parameters of blood obtained from the phase images of the cells for personalized medicine.

Our Background Publications

Our Funding

Thank you to our funding sources that continue to help us build our research work

Meet The Team

Research Trainees

Our Mentors

Events

IKP Hyderabad Event – 2018

Phase labs got award of ”Special Mentions” in category of “Pharma, Bio-pharma, Diagnostics”.

Industry Day – 2018

IIT – Delhi

Press Coverage

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Address

Technology Business Incubator Unit Synergy Building, Indian Institute of Technology, Delhi Hauz Khas, New Delhi 110 016 | Phone: 0123456789

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